Author

A. Edel

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Open access Oct 2026

rhythmCI: an R package for rhythm detection using harmonic regression amplitude confidence intervals

Background Circadian clocks are evolutionarily conserved systems that orchestrate daily rhythms in human physiology, tissue behavior, and cellular function. In circadian research, the NanoString nCounter platform has emerged as a robust alternative to microarray and RNA sequencing. However, raw instrument output requir...

J. Sreekanth, A. Edel, Claudia D. Spies et al. · bioRxiv · 0 citations

Open access Sep 2026

Personalised energy targeting during venovenous ECMO: serial assessment of resting energy expenditure reveals phase-dependent metabolic demand and systematic discordance with predictive equations

In patients receiving extracorporeal membrane oxygenation (ECMO), metabolic demand varies dynamically across the disease course, while conventional indirect calorimetry in ECMO patients underestimates measured energy expenditure (measured EE) because a substantial proportion of gas exchange occurs across the membrane l...

Sarah K. Wilke, N. Behnel, S. Weber-Carstens et al. · Critical Care · 0 citations

Open access Oct 2026

Proteome signatures in ICU patients with COVID-19 and acute brain dysfunction: an observational cohort study

Deep sedation and delirium are common in COVID-19 intensive care unit (ICU) patients. Biomarkers for prediction, detection, and monitoring are missing. Unbiased omics analyses are warranted to gain a systems biology view on pathophysiology. This prospective observational satellite study analysed the proteome signatures...

A. Edel, J. Sreekanth, Florian Kurth et al. · Scientific Reports · 0 citations