A novel approach to sustain delivery of leflunomide from floating gastro-retentive in situ gel for treatment of juvenile idiopathic arthritis: development, in-vitro and in-vivo evaluation
This study aimed to develop and evaluate a floating oral in situ gel with leflunomide (LEF) as a liquid gastro-retentive drug delivery system to increase the residence time of the drug in the stomach and sustain drug delivery. Floating in situ gel system of leflunomide was prepared using sodium alginate as a gelling po...