A. Elhenawy

Synthesis and characterization of selected new thiazolidine-2,4-diones derivatives: SwissADME and density-functional-theory analysis

The synthesis of novel thiazolidine-2,4-dione derivatives, their pharmacokinetic profile, and their structural features for drug-like potential are all covered in the current work. Thiazolidine-2,4-dione was selected as a core scaffold due to its well-established role as a privileged pharmacophore in antidiabetic drug...

Evaluation of the chemical components, cytotoxicity, antioxidant, antidiabetic, and anti-inflammatory properties of oil from Opuntia ficus indica seeds grown in the Al Baha region based on a molecular docking study

Synthesis of thiosemicarbazone derivatives of thiophene-2-carboxylic acid as potent urease inhibitors: in vitro evaluation, molecular docking, and density functional theory analysis.

AIMS To synthesize and evaluate a series of thiosemicarbazone derivatives (2a-2g) incorporating thiophene-2-carboxylic acid as urease inhibitors. MATERIALS AND METHODS The compounds were synthesized and characterized using modern spectroscopic techniques. In vitro urease inhibition was determined followed by computat...

Phytochemical characterization and bioactivity evaluation of Artemisia abyssinica methanolic extract as a baseline for bioresource exploration

The phytochemical composition of the methanolic extract of Artemisia abyssinica aerial parts was comprehensively characterized and its phytochemical richness and early-stage bioactivity were highlighted, supporting its relevance for further pharmaceutical investigation as well as its potential as a natural bioresource...

Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies.

These integrated experimental and computational results demonstrate that the polyhydroquinoline scaffold represents a promising platform for developing next-generation antidiabetic therapeutics with enhanced efficacy and favorable safety profiles.