Author

A. Elhendawy

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Oct 2026

Benzodiazepine-based N,S-heterocyclic hybrids as multi-target therapeutic candidates for cancer and inflammation: enzymatic evaluation, cellular mechanistic studies, in vivo anti-inflammatory assessment, and computational investigations.

A series of eleven novel benzodiazepine-based N, S-heterocyclic hybrids incorporating thienothiazine and thienopyrimidine scaffolds was designed, synthesized, and characterized by spectroscopic and analytical techniques. Compounds 4 and 6 showed favorable selectivity against HCT-116 and MDA-MB-231 cells relative to nor...

Hagar S. El-Hema, M. A. Abed, M. A. Hawata et al. · Bioorganic chemistry (Print) · 0 citations

Sep 2026

Synthesis, DFT, molecular docking, and insecticidal evaluation of new pyrazole-thiazole hydrazones derivatives against Tribolium castaneum.

By reacting ethyl-3-oxo-2-(2-(p bromo)hydrazono)butanoate (1) with various α-halocarbonyl compounds, such as ethyl 2-chloro-3-oxobutanoate 3 and ethyl 2-chloro-2-(aryldiazenyl) acetate 5a-d, this work produces a new series of pyrazole-thiazole derivatives 4 and 6a-e. The target compounds' structures were determined and...

A. El-Tantawy, M. Abdelaal, Mohamed R. Fouad et al. · Computational biology and ch... · 0 citations