Serial Tumor-Agnostic Plasma Profiling with a Compact NGS Panel During First-Line Therapy for Newly Diagnosed Metastatic Colorectal Cancer
Plasma circulating tumor DNA (ctDNA) profiling may complement tissue hotspot testing and reveal molecular changes during treatment of metastatic colorectal cancer (mCRC). We prospectively studied 39 patients with newly diagnosed unresectable mCRC receiving first-line therapy. Cell-free DNA was collected before treatmen...