A. F. Clark

Knock-Down of Glucocorticoid Receptor Beta (GRβ) Enhances the Ocular Hypertensive Response to Dexamethasone in C57BL/6J Mice

Topical ocular treatment with glucocorticoids (GCs) yields an increase in intraocular pressure (IOP) in a subset (~35–40%) of the human population, known as steroid responders. If treatment is continued, this ocular hypertension (OHT) can develop into GC-induced glaucoma. In mice, the GC-mediated OHT response is modula...