Roles of FMS-like Tyrosine Kinase 3 and Isocitrate Dehydrogenase Mutations in the Pathogenesis and Treatment of Acute Myeloid Leukemia
Clonal proliferation regarding immature myeloid precursors as well as subsequent bone marrow failure is hallmarks of acute myeloid leukemia (AML), which is a clinically and biologically heterogeneous hematologic malignancy. Frontline therapy is still mostly reliant on cytotoxic chemotherapy, which commonly results in...