Author

A. Fabrizi

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Review Open access Sep 2026

Living scaffolds in monogenic genodermatoses: 3D skin models for physiopathology, gene therapy, and drug testing.

Keratinocytes have been cultured in vitro for more than 50 years to produce long-lasting epithelial grafts containing stem cells, transient amplifying progenitors, and differentiated cells. They have been widely used to study the molecular mechanisms underlying skin physiology, pathology (e.g. functional alterations ca...

G. Bergamini, Gaia Andrea Gozza, A. Fabrizi et al. · Seminars in Cell and Develop... · 0 citations

Review Open access Aug 2026

Gene therapy for genodermatoses at the crossroads of innovation and clinical translation

Inherited genodermatoses are a heterogeneous group of rare monogenic disorders. Among these, epidermolysis bullosa (EB) and ichthyoses represent paradigmatic disorders characterized by severe skin fragility and hyperkeratosis, respectively, and impaired barrier function, often with profound effects on quality of life a...

A. Fabrizi, Marta Valenti, Silvia Zacchino et al. · Frontiers in Bioengineering... · 0 citations