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Review Aug 2026

Understanding Disorganization of Retinal Layers and the (potential) role in staging and management of Diabetic Retinal Disease.

PURPOSE Diabetic retinal disease (DRD) is increasingly recognized as a neurovascular disorder involving both microvascular and neurodegenerative damage. Optical coherence tomography (OCT) biomarkers such as disorganization of retinal inner layers (DRIL) and outer layers (DROL) serve as indicators of neuroretinal injury...

S. Vujosevic, C. Alovisi, C. M. Gemmy Cheung et al. · 0 citations
Aug 2026

Baseline Deep Capillary Plexus Ischemia Predicts Earlier Diabetic Retinopathy Complications Than Foveal Avascular Enlargement.

OBJECTIVE To evaluate whether diabetic macular ischemia metrics-deep capillary plexus baseline geometric perfusion deficit (GPDd) and foveal avascular zone enlargement (FAZe)-predict diabetic retinopathy (DR) complication risk and timing over a 2-year period. DESIGN Prospective observational cohort study. PARTICIPA...

K. Zhuang, Shinji Kakihara, Anna M. Busza et al. · 1 citation

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