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A. Filiano

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Open access Sep 2026

Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain

Neuronal pathology plays a prominent role in the cognitive and neuropathic symptoms of multiple sclerosis; however, little is known about these pathological signals to neurons in the brain and their consequences on cognition. Here, using a transgenic reporter of IFN signaling with spatial RNA-sequencing, we determined...

Shane M. O'Neil, H. Min, Li Xu et al. · 0 citations

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