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Open access Sep 2026

Discovery of rare antigen-specific TCRs via replicate profiling

Development of effective vaccines and targeted immunotherapies for cancer, autoimmunity, allergy, and infectious diseases requires comprehensive understanding of functionality and antigenic specificity of involved T cell clones. A major technical challenge remains the high-throughput identification of antigen-speci...

E. Egorov, V. Kriukova, I. A. Shagina et al. · 0 citations
Review Open access Sep 2026

Understanding HLA risk in immune-mediated inflammatory diseases requires antigen discovery.

Certain human leukocyte antigen (HLA) alleles occur more often in people with immune-mediated inflammatory diseases (IMIDs) than in unaffected individuals, making HLA one of the strongest inherited contributors to IMID risk. Yet how these alleles promote disease remains unclear. We argue that HLA risk has often been st...

H. ElAbd, A. Mahdy, A. Franke · 0 citations

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