Open access
Oct 2026
Gut microbiota-derived butyrate supports myocardial energetics and improves diastolic dysfunction in hypertensive HFpEF
Heart failure with preserved ejection fraction (HFpEF) is characterised by diastolic dysfunction and impaired mitochondrial oxidative phosphorylation. Unlike heart failure with reduced ejection fraction, adaptive ketone utilisation appears limited in HFpEF, suggesting the presence of metabolic bottlenecks....
S. Kedziora, S. Geisberger, O. Popp et al.
· European Heart Journal · 0 citations