The integration of copy number variant (CNV) workflows into genome sequencing (GS) analysis pipelines allows for the identification of CNVs implicated in disease. Here, we generated a novel resource of CNVs identified in the HostSeq population cohort from Canada, identified the prevalence of recurrent CNVs associated w...
Navneet Aujla, B. Thiruvahindrapuram, S. Casalino et al.· PLoS ONE· 0 citations
Malignant cells do not exist in isolation. In pancreatic ductal adenocarcinoma (PDAC), malignant cells reside within distinct spatial niches shaped by stromal, immune, endothelial, and neural compartments, and this spatial context is linked to therapeutic resistance and clinical outcome. While genomic alterations dri...
Sibyl Drissler, Noor Shakfa, Elizabeth Sunnucks et al.· Cancer Research· 0 citations
The findings define a spatially and molecularly resolved view of PDAC where epithelial states, microenvironments, and genomic alterations converge to shape disease progression, offering a basis for therapeutic targeting and stratification.
Noor Shakfa, Ferris Nowlan, Sibyl Drissler et al.· Cancer Research· 0 citations
Early after household exposure, binding and neutralising antibodies were similar in all participants, but differences in T-cell functional responses were evident in individuals who developed symptoms after SARS-CoV-2 infection.
Christopher Kandel, Jessica A. Breznik, Maureen Taylor et al.· The Lancet Microbe· 0 citations
It is reported that DDIAS is a DNA-binding effector of the CIP2A pathway in human cells and proposed that DDIAS defines a mitotic DNA repair system downstream of CIP2A that mitigates the threat of mitotic ssDNA for genome integrity.
Yibo Xue, Faisal Bin Rashed, Daniel Y. L. Mao et al.· Molecules and Cells· 1 citation
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