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A. Graybiel

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Sep 2026

Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.

It is indicated that chronic stress alters Pnoc and mRNA levels of Pnoc-expressing cells in a sex-selective and region-specific manner impacting reward structures, and that NOPR antagonism shows promising efficacy in increasing reward-related behaviors in rodents and humans.

D. Pizzagalli, Meghan E. Gallo, M. Treadway et al. · 0 citations
Open access Jul 2026

Regional and Compartmental Changes Drive Progressive Patterns of Striatal Degeneration in X‐Linked Dystonia Parkinsonism

It is proposed that the matrix compartment is more vulnerable to disease impact relative to striosomes than initially thought, and the pattern of striatal degeneration may be indicative of the breakdown of a wider cortico‐basal ganglia neural circuit over the duration of the disease.

Adelie Y S Tan, Nakhon Thai, C. Arasaratnam et al. · 0 citations

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