Attenuating NKG2D stimulation reshapes intratumoral NK cell functional state to enhance persistence and anti-tumor efficacy.
NK cell-based therapies for solid tumors are limited by poor persistence and progressive functional impairment. Here, we investigated how the strength of NKG2D stimulation shapes NK cell fate and therapeutic efficacy. Using B10G5, a MICA/B-targeting partial agonist antibody that attenuates NKG2D stimulation, we show th...