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Author

A. H. Abdullah

2 papers indexed here

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Open access Nov 2026

Synthesis, in silico studies, and in vitro evaluation of novel isoindigo inhibitors targeting wild-type and D835Y mutant FLT3

FMS-like tyrosine kinase 3 (FLT3) is a validated therapeutic target, but resistance mutations such as D835Y compromise its therapeutic utility by conferring resistance to existing inhibitors and limiting therapeutic options in FLT3-driven cancers, such as Acute Myeloid Leukemia (AML). In order to address this challenge...

Mohammed M. Abadleh, A. H. Abdullah, Ahmed Adel et al. · 0 citations
Sep 2026

Synthesis of Novel Benzoxazole–Piperazine Hybrids as Anticancer Leads: Biological, Molecular Docking, and ADMET Evaluations

The synthesized benzoxazole hybrid compounds showed promising anticancer activity with acceptable ADMET properties; however, further structural optimization and mechanistic studies are needed to validate the molecular targets and improve safety and pharmacokinetic profiles.

Mahmoud A. Al-Sha'er, A. H. Abdullah, Almeqdad Y. Habashneh et al. · 0 citations

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