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A. H. Larsen

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Open access Aug 2026

Towards a molecular understanding of the role of helix 8 in GPCR trafficking.

Helix 8 in G protein-coupled receptors (GPCRs) has recently been linked to receptor internalization (Schmidt et al.,2025, Sci. Adv. 11, eadv1499), but the molecular basis of this relationship remains unclear. Here, we examined a proposed mechanism in which helix 8 functions as a surface-active amphipathic element that...

Tommas Theiss Ehler Nielsen, J. H. Schmidt, Samir Mustafa et al. · 0 citations

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