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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Newman

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Open access Aug 2026

The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology

The third-generation antipsychotic cariprazine is a low-efficacy partial agonist of the dopamine D3 receptor (D3R). Here, we report the cryo–electron microscopy structure of cariprazine bound to D3R, establishing a framework for understanding ligand recognition in this receptor. We further determine structures of D3R i...

Eliane Hadas Yardeni, Dóra Judit Kiss, Julie Sanchez et al. · 0 citations

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