Open access
Sep 2026
Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility
Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.
Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al.
· Nature Genetics · 0 citations