Open access
Oct 2026
Metabolic Rewiring of GPC3-Targeted CAR T Cells Expressing IL-15 and HER2-Targeted CAR T Cells via the ADA1–CD26 Axis Promotes Tumor Infiltration and Limits Systemic Toxicities
Background: Chimeric antigen receptor (CAR) T-cell therapy for solid tumors is limited by inadequate T-cell persistence and tumor infiltration, as well as treatment-associated cytokine release syndrome (CRS). To address these challenges, we developed a metabolically rewired CAR T-cell (MRCAR) platform by co-expressing...
Yue Hu, Kevin Song, Ruo-Ning Wang et al.
· Biomedicines · 0 citations