Multiple sclerosis (MS) is characterized by marked heterogeneity in inflammatory activity, disability accumulation, and long-term clinical outcomes. Although disease-modifying therapies have substantially improved control of inflammatory disease activity, disability progression remains incompletely explained by treatme...
Viral infections have been associated with multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), but the associations may reflect different relationships to the disease process. This review evaluates evidence for viral involvement in disease initiation, mo...
A. Hedström· International Journal of Mol...· 0 citations
Sleep disturbances are common in individuals with psychiatric diseases and may emerge years before diagnosis. It remains unclear whether they reflect modifiable risk factors or early manifestations of psychiatric illness. We aimed to investigate how different sleep dimensions relate to the risk of subsequent psychiatri...
Jie Guo, L. M. Magnusson Hanson, T. Åkerstedt et al.· European Archives of Psychia...· 0 citations
Obesity at diagnosis was associated with worse disability outcomes primarily among individuals lacking HLA-A*02:01, suggesting that HLA class I-related immune pathways may modify the influence of excess adiposity on MS disease progression.
Jie Guo, Jing Wu, Tomas Olsson et al.· Journal of Neurology· 1 citation
Family history is a well-established risk factor for multiple sclerosis (MS), but its influence on disease progression remains unclear. We investigated whether familial MS, including degree of relatedness, is associated with baseline characteristics and disease outcomes. We included individuals with incident MS from th...
A. Hedström, Tomas Olsson, L. Alfredsson· Journal of Neurology· 0 citations
Most MS risk factors, including MS heredity, HLA-DRB1*15:01, Epstein-Barr nuclear antigen levels, smoking, and low sun exposure, were associated with both onset groups, with stronger effects in AOMS.
V. Karrenbauer, Tomas Olsson, L. Alfredsson et al.· Multiple Sclerosis· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
