AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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This study profiles 284 largely uncharacterized human transcription factors with a microfluidic methylation-sensitive DNA-binding assay, uncovering 74 new motifs and showing how DNA methylation shapes TF binding.
It is found that induction of TPRX1, a known regulator of zygotic preimplantation, leads to chromatin opening at many of its binding sites in the dark matter genome, suggesting that the genome encodes many putative transcription factors.
There is ongoing debate regarding the degree to which transcription factors (TFs) independently specify genomic binding: TF binding motifs are typically short and degenerate, yielding many more binding site predictions than observed in cells. Here we present genomic high-throughput SELEX (GHT-SELEX)—a scalable method t...
The “one-two punch” approach combining LOX inhibition with clinical DHODH inhibitor suppresses tumor growth in vivo in chemo-free setting and shows that inhibiting LOX generates targetable vulnerability to ferroptosis.
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