Open access
Oct 2026
Macrophage-specific LAMTOR2 deletion disrupts systemic iron homeostasis in mice.
It is demonstrated that LAMTOR2-dependent endosomal trafficking is a critical, previously unrecognized mechanism that stabilizes the transferrin receptor, enables essential iron recycling in macrophages and ultimately sustains systemic iron homeostasis.
Laura Homs Pérez, I. Portnaia, Markus Seifert et al.
· Haematologica · 0 citations