Treatment-driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B-cell therapy in Sjögren's disease.
OBJECTIVE To characterise whole-blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti-CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non-response. METHODS Whole-blood RNA sequencing was performed at baseline and w...