Author

A. Idbaih

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Review Open access Sep 2026

Gliomas with pleomorphic and pseudopapillary features (GPAP) are circumscribed tumors with targetable mutations, prolonged survival, and frequent tumor predisposition

Abstract DNA methylation profiling of CNS tumors led to the identification of HPAP (high‐grade glioma with pleomorphic and pseudopapillary features), a recently proposed entity with variable morphology, recurrent MAP‐kinase pathway activating events, and longer survival compared to glioblastoma. We aimed to independent...

A. Picca, Valeria Barresi, A. Trinquet et al. · Brain Pathology · 0 citations

Open access Jul 2026

Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progression.

Four astrocytoma cell lines derived from IDH-mutant astrocytomas are established and extensively characterized and evidence that NOTCH signaling contributes to the regulation of cell state balance, promoting transitions toward an astrocyte-like transcriptional program while DLL3, an anti-Notch protein, expressed by oli...

L. Garcia, C. Granotier-Beckers, D. Pineau et al. · Acta Neuropathologica Commun... · 0 citations