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Author

A. Islam

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Open access Sep 2026

Targeting DYRK1A with rationally designed pyrazine–guanidine hybrids for Alzheimer's disease: design, synthesis, and biological evaluation

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) has been implicated in the pathogenesis of Alzheimer's disease (AD) by regulating tau hyperphosphorylation and neuroinflammatory pathways, suggesting DYRK1A as an important therapeutic target. Herein, we report the rational design, synthesis and eva...

Sabiha Khan, Sumaiya Khan, Shafa Khan et al. · 0 citations
Aug 2026

Mechanistic insights into the inhibition of α-synuclein aggregation by sugar-based nanoparticles.

The pathological accumulation of α-synuclein (α-syn) into amyloid fibrils is a key hallmark of Parkinson's disease and related synucleinopathies. Inhibiting the early stages of α-syn aggregation remains a major therapeutic challenge. In this work, we report the fabrication and investigation of five sugar-based nanopart...

Danish Alam, Tanzeel Khan, Iqra Sadiq et al. · 0 citations
Open access Aug 2026

Elucidating the Antiglycation Potential of Plumbagin Against Methylglyoxal-Induced Glycation of Bovine Liver Catalase.

These findings highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation, and highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation.

Faiza Iram, Ayesha Aiman, Deepanshi Vijh et al. · 0 citations

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