Author

A. Ismail

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Aug 2026

pH-dependent anti-TfR1 NANOBODY® molecules deliver efficacious oligonucleotide payloads to muscle and CNS tissues

Extending the half-life of the anti-TfR1 NANOBODY®-ASO shuttles enhances heart, sciatic nerve, and brain exposure and enables up to 30-60% target knockdown in different CNS cell types are highlighted.

EA Hoyt, K. Moonens, C. Rapisarda et al. · bioRxiv · 0 citations