Antibacterial profiling, mechanistic characterization and in silico studies of pyrrolo[3,4-d]isoxazolidine-naphthalimide hybrids targeting Staphylococcus aureus.
In an effort to diverge from the molecular framework of conventional drug molecules, a series of pyrrolo[3,4-d]isoxazolidine-naphthalimide hybrids have been synthesized via a 1,3-dipolar cycloaddition reaction between azomethine N-oxides and N-substituted maleimide, with the aim of exploring moieties capable of lesseni...