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Author

A. Jayavelu

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4 papers indexed here

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Open access Aug 2026

FET fusion proteins reshape splicing factor networks to drive oncogenic alternative splicing

Gene fusions involving the FET gene family (FUS, EWSR1, and TAF15) act as drivers of numerous cancer entities. The resulting chimeric proteins are widely viewed as aberrant transcriptional regulators that promote malignant transformation through chromatin and enhancer reprogramming. Here, we show that FET fusion oncopr...

Loïc Ongena, Eva Lucarelli, Laurence Dubois et al. · 0 citations
Open access Sep 2026

Functional proteomic and phosphoproteomic profiling of routine FFPE CNS tumor tissue complements genomic and epigenomic characterization

Genomic and DNA methylation-based analyses have transformed the classification of central nervous system (CNS) tumors by enabling robust molecular diagnosis and subclassification. However, these approaches primarily define tumor identity and do not directly capture the functional state of intracellular signaling networ...

Dennis Friedel, Rhaissa Ribeiro da Silva, Ivan Abdulrazak Ahmed et al. · 0 citations
Open access Sep 2026

Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma

Functional experiments demonstrate that LMO7 silencing decreases clonogenicity and migratory capacity in vitro and suppresses primary tumor growth and metastatic dissemination in vivo, and illustrate how integrating functional, spatial and clinical data can uncover oncogene-driven effectors of metastasis.

Veronika Buršić, Heng Luo, C. Hénon et al. · 0 citations
Open access Aug 2026

Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma

Metastatic dissemination represents the major determinant of poor clinical outcome across cancer entities. Yet, how driver oncogenes shape transcriptional programs facilitating metastasis is poorly understood. In Ewing sarcoma (EwS) – a highly aggressive pediatric bone and soft-tissue sarcoma driven by chimeric FET::ET...

Veronika Buršić, Heng Luo, C. Hénon et al. · 0 citations

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