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Open access Sep 2026

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations

Large-scale genome sequencing analyses have identified driver gene mutations (DGMs) in most cancers as well as their associated tumorigenic mechanisms. However, a small fraction of cancers are not positive for these canonical DGMs, leaving the mechanisms underpinning their formation a mystery. We hypothesized that cano...

Misaki Kosaka, Yoshimi Okamoto-Uchida, Haruka Hirose et al. · 0 citations
Open access Sep 2026

Hox/Meis-dependent gene-regulatory transition underlies cardiopharyngeal neural crest diversification

Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks underlying their differentiation in the cardiopharyngeal region remain unclear. Here, we integrate single-cell RNA-seq, spatial transcriptomics, and multiomic analyses t...

Akiyasu Iwase, Y. Uchijima, Daiki Seya et al. · 0 citations

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