Open access
Oct 2026
Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300
It is identified that EP300 controls the growth of AKT-dysregulated osteosarcoma cells by regulating expression of state-specific genetic dependencies by synergizing with EP300 degraders to suppress osteosarcoma growth in vitro and in vivo.
Ian M. Delahunty, S. Nance, Yang Zhang et al.
· Journal of Experimental Medi... · 0 citations