Shotgun metagenomic sequencing of serum extracellular vesicle-derived DNA enables microbial profiling in urothelial carcinoma
Shotgun metagenomic sequencing provides more detailed microbial information than 16 S rRNA sequencing but requires higher cost and larger sample volumes. We evaluated whether shotgun metagenomic sequencing could detect bacterial DNA in serum extracellular vesicles. Serum samples from 72 patients with urothelial carcino...