Author

Andrew Keniry

2 papers indexed here

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Open access Oct 2026

SMCHD1 is a target for gene activation therapy to treat Prader-Willi syndrome

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by loss of expression from the active paternal allele at an imprinted cluster on chromosome 15. Current treatments address individual symptoms rather than the underlying cause of disease. Because all patients preserve a normal but epigenetically silenc...

Megan Iminitoff, Anna Le Fevre, Tamara Cameron et al. · Science Advances · 0 citations

Open access Sep 2026

SMCHD1’s DNA binding activity enables its stable retention on chromatin

It is revealed that DNA binding constrains SMCHD1 mobility and supports maintenance, rather than initial recruitment, of chromatin-bound SMCHD1 both during interphase and mitosis both during interphase and mitosis.

Rui-Feng Hu, Julissa J. Sánchez-Velásquez, Jieqiong Lou et al. · bioRxiv · 0 citations