Integrated Transcriptomic and Regulatory Network Analysis Reveals Distinct Molecular Subtypes with Prognostic Significance in Clear Cell Renal Cell Carcinoma
Background: Clear cell renal cell carcinoma (ccRCC) shows molecular heterogeneity that complicates prognosis and selection of therapy. Integration of upstream pathway activity and transcription factor (TF) regulatory networks with gene expression to define molecular subtypes remains underexplored. Methods: We harmonize...