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Open access Oct 2026

Integrated Transcriptomic and Regulatory Network Analysis Reveals Distinct Molecular Subtypes with Prognostic Significance in Clear Cell Renal Cell Carcinoma

Background: Clear cell renal cell carcinoma (ccRCC) shows molecular heterogeneity that complicates prognosis and selection of therapy. Integration of upstream pathway activity and transcription factor (TF) regulatory networks with gene expression to define molecular subtypes remains underexplored. Methods: We harmonize...

M. A. Zahid, W. Kouidri, A. Khan et al. · 0 citations
Oct 2026

Regioselective copper-catalyzed domino synthesis of 7-iodobenzo[d]oxazoles as potential ERβ ligands.

7-Halogenated benzoxazoles are a recurring motif in preclinical ligands for the estrogen receptor β (ERβ) and in other oxazole-based pharmacophores, yet selective and direct access to the 7-halo regiochemistry is not well served by classical condensation routes or by existing copper-catalyzed arylation methods. Here we...

W. K. Al-Jammal, Raed M. Al-Zoubi, Sally R. Al-Zoubi et al. · 0 citations

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