Open access
Jul 2026
Revealing NMOSD Molecular Mechanisms in an AQP4-Induced Animal Model 2261163
The findings show that NMOSD is driven by antigen-specific T and B cell responses, amplified by IFN-I and innate CNS dysregulation, and PLGA(AQP4) therapy re-establishes tolerance and offers a translational strategy for CNS autoimmunity.
G. Arellano, Mac Zelazny, T. Neef et al.
· Journal of Immunology · 0 citations