Canonical Notch2 signaling regulates development and maintenance of iron-recycling macrophages and iron homeostasis
Red pulp macrophages (RPM) and bone marrow macrophages (BMM) are iron-recycling cells, involved in iron homeostasis and erythropoiesis. Here we show, by conditional deletion strategies using Cx3cr1Cre-mediated targeting to inactivate Notch signalling components in mice, that canonical Notch2 signalling regulates the de...