Author

A. Kobro‐Flatmoen

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Open access Aug 2026

Mechanisms of resilience to autosomal dominant Alzheimer’s disease via oligogenic modulation of rare variants in the entorhinal cortex

Two PSEN1 E280A carriers have presented extreme protection against autosomal dominant Alzheimer’s disease (ADAD), with over two decades of delay for dementia onset. One of them, a male heterozygous for the RELN-COLBOS protective variant showed increased neuronal density in the entorhinal cortex 1. We conducted a deep p...

Yassir El-Amri, N. Villalba-Moreno, Julia A. Urban et al. · bioRxiv · 0 citations

Open access Aug 2026

High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer’s disease

The entorhinal cortex (EC) plays a crucial role in memory functions. Long before the clinical symptoms of Alzheimer’s disease (AD) emerge, it has already undergone significant degeneration, making it a primary site for the onset of the disease. The reasons for this remain elusive. Layer II (LII) neurons of the anterola...

A. Kobro‐Flatmoen, J. Hussan, P. Hunter et al. · PLoS Computational Biology · 0 citations