Clinical endpoints for trials of Strep A vaccines: report of two expert meetings.
Streptococcus pyogenes (group A Streptococcus; Strep A) causes a broad spectrum of diseases ranging from pharyngitis and skin infections to invasive disease and immune-mediated complications including acute rheumatic fever (ARF) and rheumatic heart disease (RHD). RHD remains one of the most important causes of cardiova...