Tardigrades are microinvertebrates known for their extreme resilience to ionizing radiation, desiccation, and other environmental stresses. This tolerance is partly attributed to efficient DNA repair mechanisms. Here, we biochemically characterized the apurinic/apyrimidinic endonuclease 1 from Hypsibius exemplaris (hex...
Anastasia M. Yakovleva, Elena S. Mikushina, M. Meschaninova et al.· DNA Repair· 0 citations
Investigation of conformational dynamics enzyme-substrate complexes using wild type enzyme and set of mutant forms of human TdT provides link between function of active site amino acids and kinetics of molecular events within individual stages of the catalytic cycle.
Svetlana S. Senchurova, A. Kuznetsova, N. Kuznetsov· International Journal of Bio...· 0 citations
Alkyladenine DNA glycosylase (AAG) is a critical enzyme in the base excision repair (BER) pathway that safeguards genome integrity by removing structurally diverse alkylated and deaminated purine lesions from DNA. It serves as a primary defense against alkylation-induced mutations, which are linked to cancer developmen...
O. A. Kladova, T. E. Tyugashev, A. Miroshnikov et al.· Biochimica et Biophysica Act...· 0 citations
It is demonstrated that non-active-site SNPs can qualitatively reprogram the substrate specificity of AAG, and could be considered as potential functional biomarkers for cancer risk and response to alkylating chemotherapy.
O. A. Kladova, T. E. Tyugashev, A. S. Bakman et al.· International Journal of Mol...· 0 citations
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