Author

A. L. Bloom

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Open access Sep 2026

Yck2 links mitochondrial function and pH homeostasis to cell wall remodeling and antifungal susceptibility in Cryptococcus neoformans

Invasive fungal infections are on the rise due to climate change, antifungal resistance, and increased usage of immunomodulating therapies. The antifungal arsenal is limited in number and in efficacy necessitating novel therapeutics. Deletion of the gene encoding the fungal yeast casein kinase, YCK2, has pleiotropic ef...

A. L. Bloom, David Goich, Eric S. Mendelson et al. · bioRxiv · 0 citations

Open access Sep 2026

Stress-dependent ribosome-associated proteomics reveals a role for Sis1 in thermotolerance and virulence in Cryptococcus neoformans

ABSTRACT During human infection, Cryptococcus neoformans can disseminate to the central nervous system, causing often-fatal cryptococcal meningitis in individuals with compromised immunity. To acutely adapt to host micro-environments, C. neoformans employs mechanisms to reprogram its translatome to provide cells with t...

Maia F. Mazzaferro, Alexandra C. Benedetto, A. L. Bloom et al. · Microbiology spectrum · 0 citations