Open access
Sep 2026
Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver.
Lipid nanoparticles (LNPs) preferentially accumulate in the liver, but hepatic tropism alone does not ensure productive RNA interference. Here, we screened a library of LNPs in which lipid composition was varied to generate distinct protein corona identities and identify formulations capable of combining liver accumula...
N. G. Sukubo, Serena Renzi, M. Violatto et al.
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