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Author

A. Laghezza

2 papers indexed here

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Oct 2026

Design and Development of New Dual Target Agents, Cannabinoid Subtype 2 Receptor (CB2R) Agonists, and Fatty Acid Amide Hydrolase (FAAH) Inhibitors against Neurodegeneration

As dual modulators of Cannabinoid subtype 2 receptor (CB2R) and fatty acid amide hydrolase (FAAH)an arising therapeutic strategy against diseases based on neuroinflammationwe developed a new series of N-adamantyl-benzamides bearing an anthranilic or salicylic scaffold. Derivatives 18, 22, and 25 emerged as an inter...

Giovanni Graziano, Francesco Mastropasqua, A. Fanizzi et al. · 0 citations
Open access Sep 2026

Structural optimization of donepezil-like hybrids toward an improved multi-target and ADME-related profile.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder involving mainly cholinergic dysfunction, protein misfolding, and metal dyshomeostasis. Considering the complexity of the pathology, multi-target approaches represent a valuable alternative to current approved mono-target treatments. In this study,...

Marco Paparella, R. Leuci, Marco Cerini et al. · 0 citations

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