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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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A. Lakshminarasimhan

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Review Sep 2026

BTNL2 As an Immunomodulatory Ligand: Delineating an Orphan Immune Checkpoint.

Butyrophilin-like 2 (BTNL2) is a Type I transmembrane glycoprotein of the immunoglobulin superfamily (IgSF) that functions as a tissue-specific immune checkpoint regulator with structural homology to B7 ligands. BTNL2 suppresses T cell activation by attenuating IL-2 secretion through the AP-1, NFAT, and NF-κB pathways....

Ishwar Patidar, Ramya Aswthareddy, A. Lakshminarasimhan et al. · 0 citations

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