Author

A. Laveck

2 papers indexed here

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Open access Sep 2026

Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

A novel approach to target RMS transcription comprising simultaneous targeting of two distinctly acting transcriptional co-activators dually targets CRC-associated co-activators to cooperatively suppress the RMS transcriptome and enforce cell death.

Alrik Gustafson, S. Nance, B. Gryder et al. · bioRxiv · 0 citations

Sep 2026

Abstract B005: Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit

Rhabdomyosarcoma (RMS) is a high-risk pediatric sarcoma that resembles developing skeletal muscle. Transcriptional dysregulation drives RMS pathogenesis in tumors carrying chimeric transcription factors (“fusion-positive (FP)”), and those without (“fusion-negative” (FN)). Here, we develop a novel approach against RMS...

Brian J. Abraham, Annika L. Gustafson, S. Nance et al. · Cancer Research · 0 citations