Author

A. Leonard

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Preprint Oct 2026

GCTAg: scalable mixed-model analysis for biobank-scale agricultural cohorts

Genome-wide association studies identify genomic variants associated with traits. Mixed linear model association (MLMA) methods using a whole-genome relationship matrix, such as those implemented in GCTA, are powerful but computationally expensive. Here, we remove key memory and CPU bottlenecks in GCTA, reducing REML m...

A. Leonard, Qiong-Yu He, Natasha Watson et al. · 0 citations

Open access Jul 2026

An endogenous retrovirus insertion disrupting bovine ALKBH8 causes a failure-to-thrive syndrome with immunodeficiency associated with juvenile mortality in Brown Swiss cattle

This study demonstrates that exploring population-scale genomic data and mining thousands of life-history records, followed by veterinary follow-up evaluations and molecular genetic analyses, provides an effective strategy for identifying cryptic recessive disorders that shorten the lifespan of cattle.

S. Glatthard, N. Kadri, F. Seefried et al. · bioRxiv · 0 citations