Review
Open access
Sep 2026
K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses
Two-pore domain potassium (K2P) channels are major determinants of neuronal excitability through their ability to generate leak potassium currents that control resting membrane potential and action potential firing. Initially considered as passive background channels, K2P channels are now recognized as polymodal sensor...
Nicolas Gilbert, Kelly Jeanne, A. Li et al.
· Frontiers in Pharmacology · 0 citations