Author

A. Llombart-Cussac

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Open access Oct 2026

5-year outcomes of chemotherapy de-escalation in HER2-positive early breast cancer and exploratory circulating tumor DNA analyses from the randomized phase 2 PHERGain trial.

PHERGain was a randomized, non-comparative phase 2 trial evaluating a positron 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG-PET)-guided, pathological complete response (pCR)-adapted strategy to omit chemotherapy in HER2-positive early breast cancer. Female patients with HER2-positive stages I-IIIA opera...

J. Pérez-García, J. Cortés, M. Ruíz-Borrego et al. · Nature Medicine · 0 citations

Open access Oct 2026

Study design of the phase III ADELA trial of elacestrant with or without everolimus in ESR1-mutated ER+/HER2- advanced breast cancer after progression on endocrine therapy plus a CDK4/6 inhibitor.

CLINICAL TRIAL REGISTRATION www.clinicaltrials.gov identifier is NCT06382948; EU Clinical Trials identifier is EUCT 2024-512926-27-00.

J. Pérez-García, A. Llombart-Cussac, E. López-Miranda et al. · Future Oncology · 0 citations

Oct 2026

Cerebrospinal fluid and plasma circulating tumor DNA dynamics as a biomarker of response during trastuzumab deruxtecan treatment in patients with breast cancer with leptomeningeal disease.

PURPOSE Leptomeningeal disease (LMD) from breast cancer remains associated with poor outcomes and there are limited tools for quantitative response assessment. We evaluated cerebrospinal fluid (CSF) circulating tumour DNA (ctDNA) as a biomarker of treatment response in patients with LMD treated with trastuzumab deruxte...

A. Fitzpatrick, T. Shanmugalingam, S. Haider et al. · Clinical Cancer Research · 0 citations

Open access Sep 2026

Impact of Prior Exposure to Anisakis simplex Antigens on Immune Response During SARS-CoV-2 Vaccination.

Parasitic infections can induce immunomodulatory effects that may influence host responses to vaccination. Chronic exposure to Anisakis antigens could modify T-cell and antibody profiles, potentially affecting SARS-CoV-2 vaccine effectiveness in endemic populations. We aimed to determine whether prior exposure to Anisa...

Carmen Cuéllar, M. Rodero, Juan González-Fernández et al. · Parasite immunology (Print) · 0 citations

Review Open access Jul 2026

Circulating tumor DNA in early breast cancer: Evidence, challenges, next steps

Evidence supporting ctDNA for early response monitoring during neoadjuvant therapy, postoperative minimal residual disease detection, and longitudinal molecular surveillance is summarized and ctDNA‐guided therapeutic interception strategies and emerging multimodal cell‐free DNA approaches are discussed.

S. Di Cosimo, V. Appierto, C. Reduzzi et al. · Cancer · 0 citations