Author

A. Locallo

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Open access Sep 2026

Recurrent mechanisms of biallelic epigenetic inactivation reveal new putative tumour suppressor genes in prostate cancer

The inactivation of tumour suppressor genes is a key step in cancer development, and is usually achieved by homozygous loss. In prostate cancer, however, large genomic regions are often hemizygously lost, which complicates the identification of putative tumour suppressors in these regions. Here, we develop Epi2Hit, an...

Daria Kiriy, Francesco Favero, C. Gerhäuser et al. · Nature Communications · 0 citations

Open access Oct 2026

Genomic alterations and treatment define spatiotemporal patterns of glioblastoma recurrence.

The surgical margin is the primary site of glioblastoma recurrence, yet its molecular features remain poorly characterized. We performed histology-guided sampling and single-cell spatial transcriptomics of surgical margin and adjacent recurrent tumor regions, with matched primary tumors from 40 patients. The surgical m...

S. Artzi, D. Harwood, A. Locallo et al. · Cancer Discovery · 0 citations