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Open access Oct 2026

Heterogeneity and Intercellular Coupling Prevent Sinus Arrest in Rabbit Sinoatrial Node Model

Abstract The sinoatrial node (SAN) is the primary pacemaker of the heart, initiating each regular heartbeat through the spontaneous activity of specialized pacemaker cells. Its automaticity is governed by a tightly regulated interplay between ionic membrane currents and intracellular calcium cycling and is highly sensi...

Michele Terren, Moritz Linder, E. Ricci et al. · 0 citations
Open access Oct 2026

Electroporation-Mediated Membrane Permeability as a Driver of Cardioversion: A Computational Study

Abstract Electrical cardioversion terminates cardiac arrhythmias by delivering direct current. Moreover, strong electrical shocks cause transient permeabilization of biological membranes, i.e., reversible electroporation. This mechanism has been suggested as a contributor to cardioversion. This study investigates wheth...

Helena Giessler, Cristian Barrios Espinosa, Moritz Linder et al. · 0 citations

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