Author

A. Lucianò

2 papers indexed here

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Open access Sep 2026

Stabilization of the PP2A-B56α complex overcomes venetoclax-azacitidine resistance by impairing OXPHOS in AML.

Cell metabolic rewiring is associated with resistance to venetoclax-azacitidine (Ven-Aza) combination therapy and relapse in acute myeloid leukemia (AML) patients. Drug-resistant cells exhibit an enhanced reliance on oxidative phosphorylation (OXPHOS) for energy production. Therefore, impairing mitochondrial metabolism...

Silvia Romero-Murillo, I. Peris, A. Lucianò et al. · JCI Insight · 0 citations

Sep 2026

Abstract A016: Polyploid giant cancer cells secrete Interferon-beta to induce chemoresistant cell states in fusion-negative rhabdomyosarcoma

Fusion-negative rhabdomyosarcoma (FN-RMS) is a childhood muscle cancer where relapse and refractory disease lead to poor outcomes. Our group has recently shown that FN-RMS is a cancer stem cell (CSC) disease and that these CD44+/CD90+/EGFR+ cells likely contribute to therapy-resistance, yet the precise mechanisms gov...

S. Mathavarajah, Tiffany C. Y. Eng, Elisa J. Quantin et al. · Cancer Research · 0 citations